Rat Sera
Sigma Aldrich Fine Chemicals Biosciences Rat serum
Rat serum is pooled from a normal donor population.
Sigma Aldrich Fine Chemicals Biosciences IgG rat serum technic100MG
IgG (immunoglobulin G) antibody is enriched in mother milk. IgG is a major class of immunoglobulin. It contributes to 10A20% of plasma protein and is regarded as one of the most abundant serum protein. It consists of four subclasses IgG1 IgG2 IgG3 and IgG4. The IgG structure possesses four polypeptide chains containing two identical³ heavy (H) chains and two identicalº or» light (L) chains of 50kDa and 25kDa respectively. The chains are interlinked with a disulfide bond. Both the L and the H chains consist of a variable domain at the N-terminal. The C-terminal bearsAE constant domains three in H chain with a hinge region and one in the L chain. The variable region of IgG antibody is specific to antigens and is highly conserved.
Sigma Aldrich Fine Chemicals Biosciences IgG from rat serum reagent50MG
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids Immunoglobins have two heavy (H) and two light (L) chains linked by disulphide linkages. Each light chain comprises one variable N-terminal region and a constant C-terminal region. Heavy chain has one variable N-terminal region and three or four constant (CH1-CH4) C-terminal region. The four classes of IgG can be IgG1 IgG2 IgG3 and IgG4. IgG antibody provides protection from infections caused by bacteria fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections. Rat IgG is purified from pooled normal rat serum by fractionation and ion-exchange chromatography.